Calcium channel blockers (CCBs) are frequently used to treat cardiovascular diseases such as hypertension amlodipine is one of the most frequently prescribed CCBs. Upon withdrawal of amlodipine, the patient’s rash gradually improved to complete resolution without any residue over 8 months (Figure 2).ĭiscussion. These results were suggestive of subacute eczematous and spongiotic dermatitis of a drug reaction with no evidence of vasculitis.
#Amlodipine pinpoint rash skin
The results of the skin biopsy returned and revealed the presence of hyperkeratosis with parakeratosis, serum overlying the epidermis, spongiosis, irregular psoriasiform hyperplasia, and a brisk superficial perivascular lymphocytic infiltrate with eosinophils. At that point, the rash was further controlled by topical steroids mixed with over-the-counter topical emollients.
#Amlodipine pinpoint rash Patch
Patch testing was also performed, but results did not show any significant positive reactions.Īfter stopping a second course of prednisone, the patient again experienced pruritus but with very gradual improvement of the rash. An aeroallergen skin test and food allergy skin test were performed, results of which did not show any significant sensitization. A skin biopsy was performed and sent for evaluation. He was prescribed H1- and H2-antagonists, as well as a tapering course of prednisone. The amlodipine was discontinued and replaced with hydrochlorothiazide. Neither mucous membrane involvement nor systemic symptoms were reported.
The skin in between each lesion was clear (Figure 1). Multiple discrete discoid, erythematous, maculopapular patches with fine scales covered most of the back. At the time of onset of the rash, the patient had taken levothyroxine, pravastatin, omeprazole, metoprolol, and amlodipine. The patient had been living by himself, denied use of new soaps or detergents, denied use of lotions or creams, and denied any other recent skin lesions, atopic symptoms, or urticaria.
He experienced little improvement of his symptoms and was referred by his primary care physician for further allergy evaluation, where he presented to our clinic. Two steroid injections were administered at an urgent care clinic 1 day apart, and the patient was started on methylprednisolone. Three days after initiating treatment, he developed an extremely pruritic rash on his back.
Sanaa Mahmoud, MD, PhD, University of Pikeville-Kentucky College of Osteopathic Medicine, 147 Sycamore Street, Pikeville, Kentucky 41501 ( 63-year-old man with hypertension was prescribed amlodipine for blood pressure control. The authors report no relevant financial relationships. Accepted August 30, 2021. Published online February 2, 2022. Amlodipine-induced eczematous drug eruption. 1Elmhurst Hospital Center, Icahn School of Medicine at Mount Sinai, New York, New YorkĢResearch Fellow, Department of Pediatrics, Ains Shams University, EgyptģUniversity of Pikeville-Kentucky College of Osteopathic Medicine, Pikeville, KentuckyĤFaculty of Medicine, Ains Shams University, EgyptĥLincoln Memorial University-DeBusk College of Osteopathic Medicine, Harrogate, TennesseeĪli A, Mahmoud S, Nguyen J.
0 kommentar(er)
